Normally, a comma indicates a small pause of some kind in a sentence. And using a “from-to” construction indicates a range. I just ran into a usage where a comma changed the type of range in a from-to construction. It’s a headline to an article about a hockey team:

From underdogs, to National Champions

Without the comma, the headline might be above an article listing teams starting with low skill and ending with the top-of-the line team. But with the comma, the meaning changes to a passage of time for one team.

Interesting.